Vedantam Laboratory Selected Publications

1. Anwar F, Sullivan AN, Viswanathan V, Vedantam G. Clostridioides difficile-Restrictive and -Permissive Gut Microbiomes. Chapter in Clostridioides difficile: Diagnostic and Clinical Perspectives (1st ed.). CRC Press. https://doi.org/10.1201/9781003583165
    
2. Roxas BAP, Roxas JL, Guo JS, LeBauer DS, McCarthy F, Vedantam G, Viswanathan VK. CAT-GxD: Centralized access to gene expression datasets. Anaerobe. 2025 Dec;96:103005. doi: 10.1016/j.anaerobe.2025.103005. Epub 2025 Oct 13. PMID: 41092974; PMCID: PMC12704217.
    
3. Kochanowsky R, Carothers K, Roxas BAP, Anwar F, Viswanathan VK, Vedantam G. Clostridioides difficile superoxide reductase mitigates oxygen sensitivity. J Bacteriol. 2024 Jul 25;206(7):e0017524. doi: 10.1128/jb.00175-24. Epub 2024 Jul 2. PMID: 38953644; PMCID: PMC11270899.
    
4. Anwar F, Clark M, Lindsey J, Claus-Walker R, Mansoor A, Nguyen E, Billy J, Lainhart W, Shehab K, Viswanathan VK, Vedantam G. Prevalence of diagnostically-discrepant Clostridioides difficile clinical specimens: insights from longitudinal surveillance. Front Med (Lausanne). 2023 Oct 18;10:1238159. doi: 10.3389/fmed.2023.1238159. PMID: 37928470; PMCID: PMC10622765.
    
5. Anwar F, Roxas BAP, Shehab KW, Ampel NM, Viswanathan VK, Vedantam G. Low-toxin Clostridioides difficile RT027 strains exhibit robust virulence. Emerg Microbes Infect. 2022 Dec;11(1):1982-1993. doi: 10.1080/22221751.2022.2105260. PMID: 35880487; PMCID: PMC9361768.
    
6. Clark AE, Adamson CC, Carothers KE, Roxas BAP, Viswanathan VK, Vedantam G. The Alternative Sigma Factor SigL Influences Clostridioides difficile Toxin Production, Sporulation, and Cell Surface Properties. Front Microbiol. 2022 May 11;13:871152. doi: 10.3389/fmicb.2022.871152. PMID: 35633701; PMCID: PMC9130780.
    
7. Roxas BAP, Roxas JL, Claus-Walker R, Harishankar A, Mansoor A, Anwar F, Jillella S, Williams A, Lindsey J, Elliott SP, Shehab KW, Viswanathan VK, Vedantam G. Phylogenomic analysis of Clostridioides difficile ribotype 106 strains reveals novel genetic islands and emergent phenotypes. Sci Rep. 2020 Dec 17;10(1):22135. doi: 10.1038/s41598-020-79123-2. PMID: 33335199; PMCID: PMC7747571.
    
8. Maseda D, Zackular JP, Trindade B, Kirk L, Roxas JL, Rogers LM, Washington MK, Du L, Koyama T, Viswanathan VK, Vedantam G, Schloss PD, Crofford LJ, Skaar EP, Aronoff DM. Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Clostridium difficile Colitis while Dysregulating the Inflammatory Response. mBio. 2019 Jan 8;10(1):e02282-18. doi: 10.1128/mBio.02282-18. PMID: 30622186; PMCID: PMC6325247.
    
9. Vedantam G, Kochanowsky J, Lindsey J, Mallozzi M, Roxas JL, Adamson C, Anwar F, Clark A, Claus-Walker R, Mansoor A, McQuade R, Monasky RC, Ramamurthy S, Roxas B, Viswanathan VK. An Engineered Synthetic Biologic Protects Against Clostridium difficile Infection. Front Microbiol. 2018 Sep 5;9:2080. doi: 10.3389/fmicb.2018.02080. eCollection 2018. PubMed PMID: 30233548; PubMed Central PMCID: PMC6134020.
    
10. Soavelomandroso AP, Gaudin F, Hoys S, Nicolas V, Vedantam G, Janoir C, Bouttier S. Biofilm Structures in a Mono-Associated Mouse Model of Clostridium difficile Infection. Front Microbiol. 2017 Oct 25;8:2086. doi: 10.3389/fmicb.2017.02086. eCollection 2017. PubMed PMID: 29118745; PubMed Central PMCID: PMC5661025.
     
11. Chu M, Mallozzi M, Roxas B, Bertolo L, Monteiro MA, Agellon A, Viswanathan VK, Vedantam G. A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence. PLoS Pathog. 2016 Oct 14;12(10):e1005946. doi: 10.1371/journal.ppat.1005946. eCollection 2016 Oct. PubMed PMID: 27741317; PubMed Central PMCID: PMC5065235.
     
12. Pantaléon V, Soavelomandroso AP, Bouttier S, Briandet R, Roxas B, Chu M, Collignon A, Janoir C, Vedantam G, Candela T. The Clostridium difficile Protease Cwp84 Modulates both Biofilm Formation and Cell-Surface Properties. PLoS One. 2015 Apr 29;10(4):e0124971. doi: 10.1371/journal.pone.0124971. eCollection 2015. PubMed PMID: 25922949; PubMed Central PMCID: PMC4414356.
     
13. Merrigan MM, Venugopal A, Roxas JL, Anwar F, Mallozzi M, Roxas B, Gerding DN, Viswanathan VK, Vedantam G. Surface-layer protein A (SlpA) is a major contributor to host-cell adherence of Clostridium difficile. PLoS One. 2013 Nov 12;8(11):e78404. doi: 10.1371/journal.pone.0078404. eCollection 2013. PubMed PMID: 24265687; PubMed Central PMCID: PMC3827033.
     
14. McQuade R, Roxas B, Viswanathan VK, Vedantam G. Clostridium difficile clinical isolates exhibit variable susceptibility and proteome alterations upon exposure to mammalian cationic antimicrobial peptides. Anaerobe. 2012 Dec;18(6):614-20. doi: 10.1016/j.anaerobe.2012.09.004. Epub 2012 Sep 24. PubMed PMID: 23017940.
     
15. Vedantam G, Clark A, Chu M, McQuade R, Mallozzi M, Viswanathan VK. Clostridium difficile infection: toxins and non-toxin virulence factors, and their contributions to disease establishment and host response. Gut Microbes. 2012 Mar-Apr;3(2):121-34. doi: 10.4161/gmic.19399. Epub 2012 Mar 1. Review. PubMed PMID: 22555464; PubMed Central PMCID: PMC3370945.
     
16. Bertolo L, Boncheff AG, Ma Z, Chen YH, Wakeford T, Friendship RM, Rosseau J, Weese JS, Chu M, Mallozzi M, Vedantam G, Monteiro MA. Clostridium difficile carbohydrates: glucan in spores, PSII common antigen in cells, immunogenicity of PSII in swine and synthesis of a dual C. difficile-ETEC conjugate vaccine. Carbohydr Res. 2012 Jun 1;354:79-86. doi: 10.1016/j.carres.2012.03.032. Epub 2012 Apr 2. PubMed PMID: 22533919.
     
17. Viswanathan VK, Mallozzi M, Vedantam G. Clostridium difficile infection: An overview of the disease and its pathogenesis, epidemiology and interventions. Gut Microbes. 2010 Jul;1(4):234-242. Epub 2010 Jun 16. PubMed PMID: 21327030; PubMed Central PMCID: PMC3023605.
     
18. Merrigan M, Venugopal A, Mallozzi M, Roxas B, Viswanathan VK, Johnson S, Gerding DN, Vedantam G. Human hypervirulent Clostridium difficile strains exhibit increased sporulation as well as robust toxin production. J Bacteriol. 2010 Oct;192(19):4904-11. doi: 10.1128/JB.00445-10. Epub 2010 Jul 30. PubMed PMID: 20675495; PubMed Central PMCID: PMC2944552.